About Enhancer
| Enhancer ID: | E_02523 |
| Species: | Mus musculus |
| Position : | chr11:72560000-72561500   |
| Year: | 2015 |
| Title: | Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 25804738 |
| MONDO: | |
| Tissue: | Midbrain |
| Tissue Ontology ID: | UBERON:0001891 |
| Cell Source: | mDA progenitors/neurons (E12.5) |
| CVCL ID: | |
| Cell Type: | dopaminergic neuron |
| Cell Ontology ID: | CL:0000700 |
| Experiment Type: | TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | ChIP-RT-qPCR, RT-RT-qPCR, Loss-of-function assay |
About Target Gene
| Target gene : | Smarca1 |
About TF
| TF name : | Foxa1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Foxa1 | AndrogenReceptor | netpath | 167 |
| Foxa1 | Direct p53 effectors | pid | 141 |
| Foxa1 | FOXA1 transcription factor network | pid | 45 |
| Foxa1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| Foxa1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer