About Enhancer
| Enhancer ID: | E_02567 |
| Species: | Homo sapiens |
| Position : | chr2:116230440-116232740   |
| Year: | 2026 |
| Title: | MYC-bound enhancer RNAs in cis regulate gene transcription and tumorigenesis. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Breast invasive carcinoma |
| PMID: | 42030388 |
| MONDO: | MONDO:0006143 |
| Tissue: | mammary gland |
| Tissue Ontology ID: | UBERON:0001911 |
| Cell Source: | BT-474 |
| CVCL ID: | CVCL_0179 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Luciferase reporter assay, loss-of-function ASO/shRNA knockdown, ChIP-qPCR, Pol II ChIA-PET chromatin interaction |
| High Throughput Method: | eCLIP-seq; ChIP-seq; ATAC-seq; RNA-seq; GRO-seq; ChIA-PET; TCGA/CCLE multi-omics |
| Low Throughput Method: | qRT-PCR, dual-luciferase reporter,; RNA FISH super-resolution imaging, subcellular fractionation, xenograft in vivo tumor assay |
About Target Gene
| Target gene : | GREB1 |
About TF
| TF name : | BRD4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
3 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02568 | chr2:116230440-116232740 | mammary gland | malignant cell | Breast invasive carcinoma |
| E_02569 | chr2:116230440-116232740 | mammary gland | malignant cell | Breast invasive carcinoma |
| E_02570 | chr2:116230440-116232740 | mammary gland | malignant cell | Breast invasive carcinoma |
Expression of Target Genes for the Enhancer