About Enhancer
| Enhancer ID: | E_02573 |
| Species: | Mus musculus |
| Position : | chrX:4899200-4899465   |
| Year: | 2009 |
| Title: | Activating Transcription Factor 2 and c-Jun-Mediated Induction of FoxP3 for Experimental Therapy of Mammary Tumor in the Mouse |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | breast carcinoma |
| PMID: | 19584292 |
| MONDO: | MONDO:0006120 |
| Tissue: | Mammary Gland |
| Tissue Ontology ID: | UBERON:0001911 |
| Cell Source: | TSA |
| CVCL ID: | CVCL_Z585 |
| Cell Type: | breast carcinoma cell |
| Cell Ontology ID: | CL:0000646 |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| High Throughput Method: | |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR |
About Target Gene
| Target gene : | Foxp3 |
About TF
| TF name : | Atf2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Atf2 | Activation of the AP-1 family of transcription factors | reactome | 10 |
| Atf2 | AndrogenReceptor | netpath | 167 |
| Atf2 | AP-1 transcription factor network | pid | 71 |
| Atf2 | Apoptosis signaling pathway | panther | 104 |
| Atf2 | ATF-2 transcription factor network | pid | 59 |
| Atf2 | BCR | netpath | 161 |
| Atf2 | CDC42 signaling events | pid | 71 |
| Atf2 | Circadian Clock | reactome | 49 |
| Atf2 | ErbB1 downstream signaling | pid | 105 |
| Atf2 | HATs acetylate histones | reactome | 142 |
| Atf2 | IL1 | netpath | 69 |
| Atf2 | IL12-mediated signaling events | pid | 62 |
| Atf2 | IL2 | netpath | 81 |
| Atf2 | IL3 | netpath | 84 |
| Atf2 | IL4 | netpath | 75 |
| Atf2 | IL5 | netpath | 59 |
| Atf2 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine | smpdb | 37 |
| Atf2 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine | smpdb | 38 |
| Atf2 | KitReceptor | netpath | 104 |
| Atf2 | Leptin | netpath | 98 |
| Atf2 | p38 cascade ( BMP2 signaling(through TAK1) ) | inoh | 8 |
| Atf2 | p38 cascade ( TGF-beta signaling(through TAK1) ) | inoh | 8 |
| Atf2 | p38 cascade ( Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, p38 cascade) ) | inoh | 13 |
| Atf2 | RAC1 signaling pathway | pid | 54 |
| Atf2 | RANKL | netpath | 84 |
| Atf2 | Ras Pathway | panther | 69 |
| Atf2 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Atf2 | Regulation of retinoblastoma protein | pid | 67 |
| Atf2 | RhoA signaling pathway | pid | 46 |
| Atf2 | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| Atf2 | TCR | netpath | 261 |
| Atf2 | TGF-beta signaling pathway | panther | 88 |
| Atf2 | TGF_beta_Receptor | netpath | 220 |
| Atf2 | TP53 Regulates Transcription of DNA Repair Genes | reactome | 61 |
| Atf2 | Transcriptional activation of mitochondrial biogenesis | reactome | 43 |
| Atf2 | TSH | netpath | 82 |
| Atf2 | p38 cascade ( IL-1 signaling pathway (through p38 cascade) ) | inoh | 16 |
| Atf2 | p38 cascade ( Toll-like receptor signaling pathway (p38 cascade) ) | inoh | 13 |
| Atf2 | MAPK signaling pathway | kegg | 264 |
| Atf2 | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| Atf2 | Hs_ATM_Signaling_Pathway_WP2516_90247 | wikipathways | 32 |
| Atf2 | Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 | wikipathways | 50 |
| Atf2 | Hs_Structural_Pathway_of_Interleukin_1_(IL-1)_WP2637_87707 | wikipathways | 34 |
| Atf2 | Hs_Energy_Metabolism_WP1541_91584 | wikipathways | 13 |
| Atf2 | Hs_TGF-beta_Signaling_Pathway_WP366_90028 | wikipathways | 67 |
| Atf2 | Hs_AGE-RAGE_pathway_WP2324_89798 | wikipathways | 27 |
| Atf2 | Hs_IL-4_Signaling_Pathway_WP395_89828 | wikipathways | 41 |
| Atf2 | Hs_IL-1_signaling_pathway_WP195_89932 | wikipathways | 34 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02572 | chrX:4899200-4899465 | Mammary Gland | breast carcinoma cell | breast carcinoma |
Expression of Target Genes for the Enhancer