About Enhancer
| Enhancer ID: | E_02587 |
| Species: | Homo sapiens |
| Position : | chr15:38850022-38850502   |
| Year: | 2019 |
| Title: | Mechanistic Characterization of RASGRP1 Variants Identifies an hnRNP-K-Regulated Transcriptional Enhancer Contributing to SLE Susceptibility. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 31164884 |
| Tissue: | kidney |
| Tissue Ontology ID: | UBERON:0002113 |
| Cell Source: | HEK293 |
| CVCL ID: | CVCL_0045 |
| Cell Type: | embryonic kidney cell |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq; RNA-seq; eQTL analysis |
| Low Throughput Method: | Luciferase Reporter Assay; EMSA; ChIP-RT-qPCR; Western blot; RT-RT-qPCR; Reporter assay; ChIP-qPCR; qPCR |
About Target Gene
| Target gene : | RASGRP1 |
About TF
| TF name : | HNRNPK |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| HNRNPK | BCR | netpath | 161 |
| HNRNPK | pre-mRNA splicing | reactome | 135 |
| HNRNPK | Processing of Capped Intron-Containing Pre-mRNA | reactome | 37 |
| HNRNPK | SUMOylation of RNA binding proteins | reactome | 46 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
3 found
Expression of Target Genes for the Enhancer