About Enhancer
| Enhancer ID: | E_02602 |
| Species: | Homo sapiens |
| Position : | chr7:94002773-94005073   |
| Year: | 2015 |
| Title: | Failed degradation of JunB contributes to overproduction of type I collagen and development of dermal fibrosis in patients with systemic sclerosis. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | systemic sclerosis |
| PMID: | 25303440 |
| MONDO: | MONDO:0005100 |
| Tissue: | connective tissue |
| Tissue Ontology ID: | UBERON:0002384 |
| Cell Source: | primary dermal fibroblasts |
| Cell Type: | fibroblast |
| Cell Ontology ID: | CL:0000057 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Gene-expression perturbation assay |
| Low Throughput Method: | Reporter assay; EMSA; ChIP; RNA interference; RT-qPCR; Western blot; immunohistochemistry |
About Target Gene
| Target gene : | COL1A2 |
About TF
| TF name : | JUND |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| JUND | AP-1 transcription factor network | pid | 71 |
| JUND | ATF-2 transcription factor network | pid | 59 |
| JUND | EGFR1 | netpath | 475 |
| JUND | Inflammation mediated by chemokine and cytokine signaling pathway | panther | 189 |
| JUND | PDGFR-beta signaling pathway | pid | 125 |
| JUND | TGF-beta signaling pathway | panther | 88 |
| JUND | TGF_beta_Receptor | netpath | 220 |
| JUND | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | pid | 37 |
| JUND | MAPK signaling pathway | kegg | 264 |
| JUND | Hs_Apoptosis-related_network_due_to_altered_Notch3_in_ovarian_cancer_WP2864_79278 | wikipathways | 51 |
| JUND | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| JUND | Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 | wikipathways | 44 |
| JUND | Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 | wikipathways | 107 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02492 | chr7:94002773-94005073 | skin of body | fibroblast | systemic sclerosis |
| E_02526 | chr7:94002773-94005073 | NA | fibroblast | systemic sclerosis |
| E_02527 | chr7:94002773-94005073 | NA | fibroblast | systemic sclerosis |
| E_02600 | chr7:94002773-94005073 | skin of body | fibroblast | systemic sclerosis |
| E_02601 | chr7:94002773-94005073 | connective tissue | fibroblast | systemic sclerosis |
| E_02615 | chr7:94002773-94005073 | lung | fibroblast | NA |
Expression of Target Genes for the Enhancer