About Enhancer
| Enhancer ID: | E_02604 |
| Species: | Homo sapiens |
| Position : | chr15:38845678-38847678   |
| Year: | 2019 |
| Title: | Mechanistic Characterization of RASGRP1 Variants Identifies an hnRNP-K-Regulated Transcriptional Enhancer Contributing to SLE Susceptibility. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | systemic lupus erythematosus |
| PMID: | 31164884 |
| MONDO: | MONDO:0007915 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Jurkat E6.1 |
| CVCL ID: | CVCL_0367 |
| Cell Type: | T cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Genetic fine-mapping; allele-specific enhancer activity; Enhancer activity assay; Disease-variant functional analysis |
| High Throughput Method: | Genetic association/meta-analysis; regulatory-epigenomic integration; eQTL analysis |
| Low Throughput Method: | Allele-specific luciferase reporter assay; RT-qPCR; Luciferase reporter assay; EMSA; ChIP-qPCR; ChIP; Allele-specific reporter assay; Reporter assay |
About Target Gene
| Target gene : | RASGRP1 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer