About Enhancer
| Enhancer ID: | E_02614 |
| Species: | Homo sapiens |
| Position : | chr15:58038775-58039647   |
| Year: | 2021 |
| Title: | Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 34643182 |
| Tissue: | alimentary part of gastrointestinal system |
| Tissue Ontology ID: | UBERON:0005409 |
| Cell Type: | embryonic cardiopulmonary progenitor cell |
| Experiment Type: | Enhancer activity assay; Comparative enhancer analysis |
| High Throughput Method: | Mouse ortholog ChIP-seq; sequence conservation |
| Low Throughput Method: | Luciferase reporter assay; enhancer motif mutation assay |
About Target Gene
| Target gene : | ALDH1A2 |
About TF
| TF name : | TBX5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TBX5 | Physiological factors | reactome | 12 |
| TBX5 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| TBX5 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer