About Enhancer
| Enhancer ID: | E_02627 |
| Species: | Homo sapiens |
| Position : | chr9:36980000-37150820   |
| Year: | 2023 |
| Title: | Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression. |
| Genome Build: | hg38 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | diffuse large B-cell lymphoma |
| PMID: | 38049665 |
| MONDO: | MONDO:0018905 |
| Tissue: | pleural effusion |
| Tissue Ontology ID: | UBERON:0000175 |
| Cell Source: | SU-DHL-10 |
| CVCL ID: | CVCL_1889 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Super-enhancer retargeting; Chromatin interaction assay; Functional perturbation assay |
| High Throughput Method: | whole-genome sequencing; H3K27ac ChIP-seq; H3K4me3 ChIP-seq; RNA-seq; Hi-C; 4C-seq |
| Low Throughput Method: | CRISPR/Cas9 HDR editing of PAX5-TSS2; PAX5-TSS2 deletion; Sanger sequencing; RT-qPCR; northern blot; ribosome/RNA-processing assays |
About Target Gene
| Target gene : | ZCCHC7 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer