About Enhancer
| Enhancer ID: | E_02651 |
| Species: | Homo sapiens |
| Position : | chr6:53306407-53314482   |
| Year: | 2025 |
| Title: | Super-enhancer-driven ELOVL5 promotes T-ALL progression through the MYC-SERBP1 pathway. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 41016515 |
| MONDO: | MONDO:0004963 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | J.gamma1 |
| CVCL ID: | CVCL_6410 |
| Cell Type: | T cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Super-enhancer identification assay; Functional perturbation assay; Transcriptomic pathway analysis; Chromatin-state profiling; In vivo functional validation |
| High Throughput Method: | H3K27ac ChIP-seq; RNA-seq; ChIP-seq |
| Low Throughput Method: | shRNA-mediated ELOVL5 knockdown; Cell proliferation assay; Apoptosis assay; SERBP1 knockdown; Mouse xenograft tumor-burden and survival assay; ChIP; In vivo phenotyping; Xenograft/xenotransplant |
About Target Gene
| Target gene : | ELOVL5 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer