About Enhancer
| Enhancer ID: | E_02704 |
| Species: | Homo sapiens |
| Position : | chr1:32753965-32762956   |
| Year: | 2026 |
| Title: | Super-enhancer-driven KIAA1522 upregulation suppresses ferroptosis in hepatocellular carcinoma. |
| Genome Build: | hg38 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | hepatocellular carcinoma |
| PMID: | 42281194 |
| MONDO: | MONDO:0007256 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | Hep-G2 |
| CVCL ID: | CVCL_0027 |
| Cell Type: | hepatoblast |
| Cell Ontology ID: | CL:0005026 |
| Experiment Type: | Super-enhancer activity assay; Functional perturbation assay; Enhancer activity assay; Endogenous enhancer perturbation; Chromatin-state profiling; In vivo functional validation |
| High Throughput Method: | H3K27ac ChIP-seq; H3K4me1 ChIP-seq; H3K4me3 ChIP-seq; BRD4 ChIP-seq; RNA-seq; ChIP-seq |
| Low Throughput Method: | Dual-luciferase reporter assay; CRISPRi using dCas9-KRAB; BRD4 ChIP-qPCR; BRD4 knockdown; JQ1 treatment; i-BET151 treatment; RT-qPCR; Western blot; CRISPRi; Luciferase reporter assay; ChIP; In vivo phenotyping; Reporter assay |
About Target Gene
| Target gene : | KIAA1522 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02705 | chr1:32753965-32762956 | liver | hepatocyte | hepatocellular carcinoma |
Expression of Target Genes for the Enhancer