About Enhancer
| Enhancer ID: | E_02711 |
| Species: | Homo sapiens |
| Position : | chr1:42614062-42616745   |
| Year: | 2022 |
| Title: | A ζ±-Catenin-TCF-Sensitive Locus Control Region Mediates GUCY2C Ligand Loss in Colorectal Cancer. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal cancer |
| PMID: | 34954189 |
| MONDO: | MONDO:0005575 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | HCT 116 |
| CVCL ID: | CVCL_0291 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay; Enhancer activity assay; Endogenous enhancer perturbation; Chromatin-state profiling |
| High Throughput Method: | ChIP-seq, RNA-seq; RNA-seq; ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout, CRISPRi, CRISPRa, ChIP-RT-qPCR, RT-RT-qPCR; CRISPR-Cas9 endogenous deletion/editing; Luciferase reporter assay; ChIP |
About Target Gene
| Target gene : | GUCA2A |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Repressed |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02716 | chr1:42614062-42616745 | bone marrow | malignant cell | acute myeloid leukemia |
Expression of Target Genes for the Enhancer