About Enhancer
| Enhancer ID: | E_02712 |
| Species: | Homo sapiens |
| Position : | chr2:11633299-11641134   |
| Year: | 2018 |
| Title: | Genome-wide analysis reveals a role for TDG in estrogen receptor-mediated enhancer RNA transcription and 3-dimensional reorganization. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Breast Cancer |
| PMID: | 29378668 |
| MONDO: | MONDO:0007254 |
| Tissue: | breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | MCF-7 |
| CVCL ID: | CVCL_0031 |
| Experiment Type: | TF-binding/chromatin assay; Chromatin interaction assay; Endogenous enhancer perturbation; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | CRISPR-Cas9 targeted editing/deletion; ChIP-qPCR/ChIP; 3C; RT-qPCR/qPCR |
About Target Gene
| Target gene : | GREB1 |
About TF
| TF name : | TDG |
About Regulatory State
| Regulatory State : | Inactive |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TDG | Cleavage of the damaged pyrimidine | reactome | 8 |
| TDG | Displacement of DNA glycosylase by APEX1 | reactome | 9 |
| TDG | Recognition and association of DNA glycosylase with site containing an affected pyrimidine | reactome | 8 |
| TDG | SUMOylation of DNA damage response and repair proteins | reactome | 76 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer