About Enhancer
| Enhancer ID: | E_02749 |
| Species: | Homo sapiens |
| Position : | chr10:51546800-51547317   |
| Year: | 2016 |
| Title: | Chromatin interactions and candidate genes at ten prostate cancer risk loci. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | prostate cancer |
| PMID: | 26979803 |
| MONDO: | MONDO:0008315 |
| Tissue: | prostate gland |
| Tissue Ontology ID: | UBERON:0002367 |
| Cell Source: | LNCaP |
| CVCL ID: | CVCL_0395 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay, TF binding assay; Chromatin interaction assay; Disease-variant functional analysis |
| High Throughput Method: | Capture 3C-seq, ChIP-seq, RNA-seq, SNP genotyping array; eQTL analysis; GWAS |
| Low Throughput Method: | Luciferase reporter assay, Site-directed mutagenesis, 3C-qPCR, RT-qPCR; 3C |
About Target Gene
| Target gene : | ANTXRLP1 |
About TF
| TF name : | FOXA1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOXA1 | AndrogenReceptor | netpath | 167 |
| FOXA1 | Direct p53 effectors | pid | 141 |
| FOXA1 | FOXA1 transcription factor network | pid | 45 |
| FOXA1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| FOXA1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
15 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02744 | chr10:51546800-51547317 | uterine cervix | malignant cell | cervical cancer |
| E_02745 | chr10:51546800-51547317 | prostate gland | malignant cell | prostate cancer |
| E_02746 | chr10:51546800-51547317 | uterine cervix | malignant cell | cervical cancer |
| E_02747 | chr10:51546800-51547317 | prostate gland | malignant cell | prostate cancer |
| E_02748 | chr10:51546800-51547317 | uterine cervix | malignant cell | cervical cancer |
| E_02750 | chr10:51546800-51547317 | uterine cervix | malignant cell | cervical cancer |
| E_02751 | chr10:51546800-51547317 | prostate gland | malignant cell | prostate cancer |
| E_02800 | chr10:51546800-51547317 | prostate gland | NA | prostate cancer |
| E_02801 | chr10:51546800-51547317 | prostate gland | NA | prostate cancer |
| E_02802 | chr10:51546800-51547317 | prostate gland | NA | prostate cancer |
| E_02803 | chr10:51546800-51547317 | prostate gland | NA | prostate cancer |
| E_02821 | chr10:51546800-51547317 | prostate gland | NA | NA |
| E_02822 | chr10:51546800-51547317 | prostate gland | NA | NA |
| E_02823 | chr10:51546800-51547317 | prostate gland | NA | NA |
| E_02824 | chr10:51546800-51547317 | prostate gland | NA | NA |
Expression of Target Genes for the Enhancer