About Enhancer
| Enhancer ID: | E_02820 |
| Species: | Homo sapiens |
| Position : | chr8:128540000-128620000   |
| Year: | 2016 |
| Title: | Chromatin interactions and candidate genes at ten prostate cancer risk loci. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | salivary gland adenoid cystic carcinoma |
| PMID: | 26979803 |
| MONDO: | MONDO:0003175 |
| Tissue: | saliva-secreting gland |
| Tissue Ontology ID: | UBERON:0001044 |
| Cell Source: | ACC patient-derived xenograft cell lines (ACCX2, ACCX9, ACCX12, ACCX19, ACCX22) |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Chromatin interaction assay, TF binding assay |
| High Throughput Method: | 4C-seq; ChIP-seq; RNA-seq; 3C; eQTL analysis |
| Low Throughput Method: | qRT-PCR, and ChIP-qPCR |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | AR |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| AR | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | reactome | 65 |
| AR | Alpha6Beta4Integrin | netpath | 74 |
| AR | AndrogenReceptor | netpath | 167 |
| AR | Coregulation of Androgen receptor activity | pid | 61 |
| AR | FOXA1 transcription factor network | pid | 45 |
| AR | IL6 | netpath | 85 |
| AR | Nongenotropic Androgen signaling | pid | 31 |
| AR | Notch-mediated HES/HEY network | pid | 48 |
| AR | Nuclear Receptor transcription pathway | reactome | 51 |
| AR | Regulation of Androgen receptor activity | pid | 54 |
| AR | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| AR | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| AR | TGF_beta_Receptor | netpath | 220 |
| AR | Oocyte meiosis | kegg | 110 |
| AR | Pathways in cancer | kegg | 321 |
| AR | Prostate cancer | kegg | 85 |
| AR | Hs_DNA_Damage_Response_WP707_82937 | wikipathways | 28 |
| AR | Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694 | wikipathways | 28 |
| AR | Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 | wikipathways | 122 |
| AR | Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 | wikipathways | 33 |
| AR | Hs_Androgen_receptor_signaling_pathway_WP138_79958 | wikipathways | 27 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
19 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02842 | chr8:128520000-128551676 | stomach | malignant cell | esophageal adenocarcinoma |
| E_02843 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02844 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02845 | chr8:128520000-128551676 | stomach | malignant cell | esophageal adenocarcinoma |
| E_02846 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02847 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02848 | chr8:128520000-128551676 | stomach | malignant cell | esophageal adenocarcinoma |
| E_02849 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02850 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02851 | chr8:128520000-128551676 | stomach | malignant cell | esophageal adenocarcinoma |
| E_02852 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02853 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02887 | chr8:128520000-128551676 | prostate gland | NA | NA |
| E_02888 | chr8:128520000-128551676 | prostate gland | NA | NA |
| E_02889 | chr8:128520000-128551676 | prostate gland | NA | NA |
| E_02890 | chr8:128520000-128551676 | prostate gland | NA | NA |
| E_02858 | chr8:128540000-128620000 | prostate gland | malignant cell | prostate cancer |
| E_04546 | chr8:128588859-128589357 | prostate gland | malignant cell | prostate cancer |
| E_04625 | chr8:128589642-128590670 | prostate gland | malignant cell | prostate cancer |
Expression of Target Genes for the Enhancer