About Enhancer
| Enhancer ID: | E_02835 |
| Species: | Homo sapiens |
| Position : | chr1:204518514-204561889   |
| Year: | 2016 |
| Title: | Chromatin interactions and candidate genes at ten prostate cancer risk loci. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | prostate cancer |
| PMID: | 26979803 |
| MONDO: | MONDO:0008315 |
| Tissue: | prostate gland |
| Tissue Ontology ID: | UBERON:0002367 |
| Cell Source: | DU145 |
| CVCL ID: | CVCL_0105 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Chromatin interaction assay, TF binding assay, Gene expression assay; Chromatin interaction assay; Disease-variant functional analysis |
| High Throughput Method: | Capture 3C-seq, ChIP-seq, RNA-seq, SNP genotyping array; eQTL analysis; GWAS |
| Low Throughput Method: | 3C-qPCR, RT-qPCR; 3C |
About Target Gene
| Target gene : | PPP1R15B |
About TF
| TF name : | AR |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| AR | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | reactome | 65 |
| AR | Alpha6Beta4Integrin | netpath | 74 |
| AR | AndrogenReceptor | netpath | 167 |
| AR | Coregulation of Androgen receptor activity | pid | 61 |
| AR | FOXA1 transcription factor network | pid | 45 |
| AR | IL6 | netpath | 85 |
| AR | Nongenotropic Androgen signaling | pid | 31 |
| AR | Notch-mediated HES/HEY network | pid | 48 |
| AR | Nuclear Receptor transcription pathway | reactome | 51 |
| AR | Regulation of Androgen receptor activity | pid | 54 |
| AR | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| AR | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| AR | TGF_beta_Receptor | netpath | 220 |
| AR | Oocyte meiosis | kegg | 110 |
| AR | Pathways in cancer | kegg | 321 |
| AR | Prostate cancer | kegg | 85 |
| AR | Hs_DNA_Damage_Response_WP707_82937 | wikipathways | 28 |
| AR | Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694 | wikipathways | 28 |
| AR | Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 | wikipathways | 122 |
| AR | Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 | wikipathways | 33 |
| AR | Hs_Androgen_receptor_signaling_pathway_WP138_79958 | wikipathways | 27 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
15 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02834 | chr1:204518514-204561889 | prostate gland | malignant cell | prostate cancer |
| E_02836 | chr1:204518514-204561889 | prostate gland | malignant cell | prostate cancer |
| E_02837 | chr1:204518514-204561889 | prostate gland | malignant cell | prostate cancer |
| E_02838 | chr1:204518514-204561889 | prostate gland | malignant cell | prostate cancer |
| E_02839 | chr1:204518514-204561889 | prostate gland | malignant cell | prostate cancer |
| E_02840 | chr1:204518514-204561889 | prostate gland | malignant cell | prostate cancer |
| E_02841 | chr1:204518514-204561889 | prostate gland | malignant cell | prostate cancer |
| E_02866 | chr1:204518514-204561889 | prostate gland | prostate epithelial cell | NA |
| E_02867 | chr1:204518514-204561889 | prostate gland | prostate epithelial cell | NA |
| E_02868 | chr1:204518514-204561889 | prostate gland | prostate epithelial cell | NA |
| E_02869 | chr1:204518514-204561889 | prostate gland | prostate epithelial cell | NA |
| E_02883 | chr1:204518514-204561889 | prostate gland | NA | NA |
| E_02884 | chr1:204518514-204561889 | prostate gland | NA | NA |
| E_02885 | chr1:204518514-204561889 | prostate gland | NA | NA |
| E_02886 | chr1:204518514-204561889 | prostate gland | NA | NA |
Expression of Target Genes for the Enhancer