About Enhancer
| Enhancer ID: | E_02839 |
| Species: | Mus musculus |
| Position : | chr4:55559000-55560500   |
| Year: | 2017 |
| Title: | A dynamic interplay of enhancer elements regulates Klf4 expression in naive pluripotency |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 28982762 |
| MONDO: | |
| Tissue: | Embryo |
| Tissue Ontology ID: | UBERON:0000922 |
| Cell Source: | Mouse JM8.N4 ESCs |
| CVCL ID: | CVCL_2155 |
| Cell Type: | mouse embryonic stem cell |
| Cell Ontology ID: | CL:0002322 |
| Experiment Type: | Functional perturbation assay |
| High Throughput Method: | ChIP-exo, ATAC-seq, RNA-seq |
| Low Throughput Method: | CRISPR Knockout, Luciferase Reporter Assay, RT-RT-qPCR, ChIP-RT-qPCR |
About Target Gene
| Target gene : | Klf4 |
About TF
| TF name : | Pou5F1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Pou5F1 | HIF-2-alpha transcription factor network | pid | 34 |
| Pou5F1 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 |
| Pou5F1 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| Pou5F1 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| Pou5F1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Pou5F1 | Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 | wikipathways | 12 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer