About Enhancer
| Enhancer ID: | E_02846 |
| Species: | Homo sapiens |
| Position : | chr8:128520000-128551676   |
| Year: | 2016 |
| Title: | Chromatin interactions and candidate genes at ten prostate cancer risk loci. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | prostate cancer |
| PMID: | 26979803 |
| MONDO: | MONDO:0008315 |
| Tissue: | prostate gland |
| Tissue Ontology ID: | UBERON:0002367 |
| Cell Source: | DU145 |
| CVCL ID: | CVCL_0105 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Chromatin interaction assay, TF binding assay, Gene expression assay; Chromatin interaction assay; Disease-variant functional analysis |
| High Throughput Method: | Capture 3C-seq, ChIP-seq, RNA-seq, SNP genotyping array; eQTL analysis; GWAS |
| Low Throughput Method: | 3C-qPCR, RT-qPCR; 3C |
About Target Gene
| Target gene : | PCAT1 |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
19 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02842 | chr8:128520000-128551676 | stomach | malignant cell | esophageal adenocarcinoma |
| E_02843 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02844 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02845 | chr8:128520000-128551676 | stomach | malignant cell | esophageal adenocarcinoma |
| E_02847 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02848 | chr8:128520000-128551676 | stomach | malignant cell | esophageal adenocarcinoma |
| E_02849 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02850 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02851 | chr8:128520000-128551676 | stomach | malignant cell | esophageal adenocarcinoma |
| E_02852 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02853 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02887 | chr8:128520000-128551676 | prostate gland | NA | NA |
| E_02888 | chr8:128520000-128551676 | prostate gland | NA | NA |
| E_02889 | chr8:128520000-128551676 | prostate gland | NA | NA |
| E_02890 | chr8:128520000-128551676 | prostate gland | NA | NA |
| E_01817 | chr8:128526339-128526710 | kidney | malignant cell | renal cell carcinoma |
| E_01851 | chr8:128526339-128526710 | kidney | kidney proximal tubule epithelial cell | NA |
| E_02820 | chr8:128540000-128620000 | saliva-secreting gland | malignant cell | salivary gland adenoid cystic carcinoma |
| E_02858 | chr8:128540000-128620000 | prostate gland | malignant cell | prostate cancer |
Expression of Target Genes for the Enhancer