About Enhancer
| Enhancer ID: | E_02878 |
| Species: | Mus musculus |
| Position : | chr6:122698567-122721126   |
| Year: | 2025 |
| Title: | Enhancer cooperativity can compensate for loss of activity over large genomic distances |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 39626663 |
| MONDO: | |
| Tissue: | Embryo |
| Tissue Ontology ID: | UBERON:0000922 |
| Cell Source: | Mouse Embryonic Stem Cells (v6.5) |
| CVCL ID: | |
| Cell Type: | mouse embryonic stem cell |
| Cell Ontology ID: | CL:0002322 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ChIP-seq, ATAC-seq |
| Low Throughput Method: | Luciferase Reporter Assay, Fluorescent Reporter Assay (mCherry), Flow-FISH, RT-RT-qPCR |
About Target Gene
| Target gene : | Nanog |
About TF
| TF name : | Nanog |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Nanog | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 |
| Nanog | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| Nanog | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer