About Enhancer
| Enhancer ID: | E_02879 |
| Species: | Mus musculus |
| Position : | chr15:79850614-79850824   |
| Year: | 2022 |
| Title: | A SOX17-PDGFB signaling axis regulates aortic root development |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 35831318 |
| MONDO: | |
| Tissue: | Heart |
| Tissue Ontology ID: | UBERON:0000948 |
| Cell Source: | Mouse Cardiac Endothelial Cells (MCECs) |
| CVCL ID: | |
| Cell Type: | cardiac endothelial cell |
| Cell Ontology ID: | CL:0000115 |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, qRT-PCR, Western blot |
About Target Gene
| Target gene : | Pdgfb |
About TF
| TF name : | Sox17 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Sox17 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| Sox17 | Wnt signaling pathway | kegg | 135 |
| Sox17 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer