About Enhancer
| Enhancer ID: | E_02891 |
| Species: | Mus musculus |
| Position : | chr11:119715961-119716245   |
| Year: | 2013 |
| Title: | Hypoxic adaptation engages the CBP/CREST-induced coactivator complex of Creb-HIF-1?|?? in transactivating murine neuroblastic glucose transporter |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 23321477 |
| MONDO: | |
| Tissue: | Brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | Neuro-2a (N2A) cells |
| CVCL ID: | CVCL_0470 |
| Cell Type: | neuroblastoma cell |
| Cell Ontology ID: | CL:0000031 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | |
| Low Throughput Method: | Luciferase reporter assay, ChIP-qPCR, EMSA |
About Target Gene
| Target gene : | Slc2A3 |
About TF
| TF name : | Hif1A |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Hif1A | Angiogenesis | panther | 141 |
| Hif1A | AP-1 transcription factor network | pid | 71 |
| Hif1A | BMAL1:CLOCK,NPAS2 activates circadian gene expression | reactome | 42 |
| Hif1A | Circadian Clock | reactome | 49 |
| Hif1A | HIF-1-alpha transcription factor network | pid | 67 |
| Hif1A | Hypoxia response via HIF activation | panther | 16 |
| Hif1A | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | pid | 19 |
| Hif1A | Notch-mediated HES/HEY network | pid | 48 |
| Hif1A | NOTCH1 Intracellular Domain Regulates Transcription | reactome | 47 |
| Hif1A | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | reactome | 18 |
| Hif1A | Parkinson disease | panther | 85 |
| Hif1A | PTK6 Expression | reactome | 5 |
| Hif1A | PTK6 promotes HIF1A stabilization | reactome | 6 |
| Hif1A | Regulation of gene expression by Hypoxia-inducible Factor | reactome | 10 |
| Hif1A | VEGF signaling pathway | panther | 54 |
| Hif1A | VEGFR1 specific signals | pid | 29 |
| Hif1A | mTOR signaling pathway | kegg | 50 |
| Hif1A | Pathways in cancer | kegg | 321 |
| Hif1A | Renal cell carcinoma | kegg | 65 |
| Hif1A | Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640 | wikipathways | 36 |
| Hif1A | Hs_Focal_Adhesion-PI3K-Akt-mTOR-signaling_pathway_WP3932_91101 | wikipathways | 8 |
| Hif1A | Hs_AGE-RAGE_pathway_WP2324_89798 | wikipathways | 27 |
| Hif1A | Hs_Notch_Signaling_Pathway_WP61_78592 | wikipathways | 16 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer