About Enhancer
| Enhancer ID: | E_02909 |
| Species: | Homo sapiens |
| Position : | chr11:101981958-101982137   |
| Year: | 2012 |
| Title: | Wnt/ζ±-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cells. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal cancer |
| PMID: | 22337891 |
| MONDO: | MONDO:0005575 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | HCT 116,SW620,SW480,RKO |
| CVCL ID: | CVCL_0291 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP |
About Target Gene
| Target gene : | YAP1 |
About TF
| TF name : | TCF4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TCF4 | AndrogenReceptor | netpath | 167 |
| TCF4 | CDO in myogenesis | reactome | 29 |
| TCF4 | Coregulation of Androgen receptor activity | pid | 61 |
| TCF4 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| TCF4 | ID | netpath | 38 |
| TCF4 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| TCF4 | TGF_beta_Receptor | netpath | 220 |
| TCF4 | Wnt | netpath | 118 |
| TCF4 | Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 | wikipathways | 41 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02752 | chr11:101981958-101982582 | colon | epithelial cell | colorectal carcinoma |
| E_02923 | chr11:101981958-101982582 | lymph node | epithelial cell | colorectal carcinoma |
| E_02925 | chr11:101981958-101982582 | colon | epithelial cell | colorectal carcinoma |
| E_02926 | chr11:101981958-101982582 | colon | epithelial cell | colorectal carcinoma |
| E_02927 | chr11:101981958-101982582 | colon | epithelial cell | colorectal carcinoma |
| E_02928 | chr11:101981958-101982582 | colon | epithelial cell | colorectal carcinoma |
Expression of Target Genes for the Enhancer