About Enhancer
| Enhancer ID: | E_02921 |
| Species: | Mus musculus |
| Position : | chr10:72782000-72783500   |
| Year: | 2017 |
| Title: | Krox20 hindbrain regulation incorporates multiple modes of cooperation between cis-acting elements |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 28749941 |
| MONDO: | |
| Tissue: | Brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | Primary mouse embryonic hindbrain cells |
| CVCL ID: | |
| Cell Type: | embryonic hindbrain neuron |
| Cell Ontology ID: | CL:0000540 |
| Experiment Type: | Functional perturbation assay |
| High Throughput Method: | ChIP-seq, ATAC-seq, RNA-seq |
| Low Throughput Method: | CRISPR Knockout, Luciferase Reporter Assay, 3C, RT-RT-qPCR |
About Target Gene
| Target gene : | Egr2 |
About TF
| TF name : | Egr2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Egr2 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| Egr2 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| Egr2 | IL4-mediated signaling events | pid | 66 |
| Egr2 | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| Egr2 | Validated transcriptional targets of TAp63 isoforms | pid | 54 |
| Egr2 | Hs_Fatty_Acid_Beta_Oxidation_WP143_79783 | wikipathways | 14 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer