About Enhancer
| Enhancer ID: | E_02924 |
| Species: | Mus musculus |
| Position : | chr1:136170803-136192554   |
| Year: | 2017 |
| Title: | MyoD- and FoxO3-mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation |
| Genome Build: | mm10 |
| Enhancer Type: | Super-enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 28575289 |
| MONDO: | |
| Tissue: | Skeletal muscle |
| Tissue Ontology ID: | UBERON:0001134 |
| Cell Source: | Mouse myoblast/myotube cell |
| CVCL ID: | CVCL_0188 |
| Cell Type: | myoblast/myotube |
| Cell Ontology ID: | CL:0000187 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ChIP-seq, RNA-seq, 3C-seq |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, CRISPR Knockout, RT-RT-qPCR, Western blot, Immunofluorescence Staining |
About Target Gene
| Target gene : | Myog |
About TF
| TF name : | Myod1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Myod1 | C-MYB transcription factor network | pid | 87 |
| Myod1 | CDO in myogenesis | reactome | 29 |
| Myod1 | ID | netpath | 38 |
| Myod1 | Notch-mediated HES/HEY network | pid | 48 |
| Myod1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Myod1 | Regulation of retinoblastoma protein | pid | 67 |
| Myod1 | Signaling events mediated by HDAC Class III | pid | 41 |
| Myod1 | Hs_ID_signaling_pathway_WP53_67360 | wikipathways | 8 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
13 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02923 | chr1:136170800-136171203 | Skeletal muscle | myoblast/myotube | -- |
| E_02920 | chr1:136170803-136192554 | Skeletal muscle | myoblast | -- |
| E_02925 | chr1:136171700-136172103 | Skeletal muscle | myoblast/myotube | -- |
| E_02926 | chr1:136177900-136178345 | Skeletal muscle | myoblast/myotube | -- |
| E_02950 | chr1:136178700-136179145 | Skeletal muscle | myoblast | -- |
| E_03298 | chr1:136179600-136180045 | Skeletal muscle | myoblast | -- |
| E_03013 | chr1:136179654-136180057 | Skeletal muscle | myoblast | -- |
| E_02927 | chr1:136180500-136180903 | Skeletal muscle | myoblast/myotube | -- |
| E_02928 | chr1:136184128-136184880 | Skeletal muscle | myoblast/myotube | -- |
| E_02969 | chr1:136185800-136186245 | Skeletal muscle | myoblast | -- |
| E_03014 | chr1:136185854-136186299 | Skeletal muscle | myoblast | -- |
| E_03305 | chr1:136188400-136188845 | Skeletal muscle | myoblast | -- |
| E_03015 | chr1:136188454-136188857 | Skeletal muscle | myoblast | -- |
Expression of Target Genes for the Enhancer