About Enhancer
| Enhancer ID: | E_02933 |
| Species: | Mus musculus |
| Position : | chr3:94170946-94172113   |
| Year: | 2021 |
| Title: | SOX-5 activates a novel ROR?|??t enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | experimental autoimmune encephalomyelitis |
| PMID: | 33473108 |
| MONDO: | MONDO:0005257 |
| Tissue: | Spleen |
| Tissue Ontology ID: | UBERON:0002106 |
| Cell Source: | Naive CD4+ T cells |
| CVCL ID: | |
| Cell Type: | naive CD4-positive T cell |
| Cell Ontology ID: | CL:0000896 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR knockout, ChIP-RT-qPCR, 3C-RT-qPCR, ChIP-loop assay, RT-RT-qPCR, Western blot, Co-IP, Flow cytometry, ELISA |
About Target Gene
| Target gene : | Rorc |
About TF
| TF name : | Sox5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Sox5 | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| Sox5 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer