About Enhancer
| Enhancer ID: | E_02936 |
| Species: | Mus musculus |
| Position : | chr3:128750000-128770000   |
| Year: | 2019 |
| Title: | Long-range Pitx2c enhancer-promoter interactions prevent predisposition to atrial fibrillation |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | atrial fibrillation |
| PMID: | 31636200 |
| MONDO: | MONDO:0004978 |
| Tissue: | Heart |
| Tissue Ontology ID: | UBERON:0000948 |
| Cell Source: | Left Atrial Cardiomyocytes |
| CVCL ID: | |
| Cell Type: | atrial cardiomyocyte |
| Cell Ontology ID: | CL:0000746 |
| Experiment Type: | Functional perturbation assay, Chromatin interaction assay, Enhancer activity assay |
| High Throughput Method: | 4C-seq, ChIP-seq, ATAC-seq, RNA-seq |
| Low Throughput Method: | CRISPR Knockout, RT-RT-qPCR, Programmed Intracardiac Pacing |
About Target Gene
| Target gene : | Pitx2C |
About TF
| TF name : | Ctcf |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Ctcf | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| Ctcf | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer