About Enhancer
| Enhancer ID: | E_02937 |
| Species: | Homo sapiens |
| Position : | chr7:117085371-117085720   |
| Year: | 2013 |
| Title: | Immune mediators regulate CFTR expression through a bifunctional airway-selective enhancer. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 23689137 |
| Tissue: | bronchus |
| Tissue Ontology ID: | UBERON:0002185 |
| Cell Source: | 16HBE14o- |
| CVCL ID: | CVCL_0112 |
| Cell Type: | bronchial epithelial cell |
| Cell Ontology ID: | CL:0002328 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Functional perturbation assay |
| High Throughput Method: | H3K4me1 chromatin profiling; DNase hypersensitivity profiling |
| Low Throughput Method: | Luciferase reporter assay; DNase I footprinting; EMSA; ChIP-qPCR; siRNA knockdown; RT-qPCR |
About Target Gene
| Target gene : | CFTR |
About TF
| TF name : | IRF1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| IRF1 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| IRF1 | Glucocorticoid receptor regulatory network | pid | 85 |
| IRF1 | IFN-gamma pathway | pid | 43 |
| IRF1 | IL12 signaling mediated by STAT4 | pid | 33 |
| IRF1 | IL6-mediated signaling events | pid | 48 |
| IRF1 | Interferon alpha/beta signaling | reactome | 67 |
| IRF1 | Interferon gamma signaling | reactome | 88 |
| IRF1 | Regulation of Telomerase | pid | 70 |
| IRF1 | TRAF6 mediated IRF7 activation | reactome | 33 |
| IRF1 | Hepatitis C | kegg | 134 |
| IRF1 | Hs_Tryptophan_metabolism_WP465_85055 | wikipathways | 45 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00040 | chr7:117084000-117086500 | bronchus | bronchial epithelial cell | NA |
Expression of Target Genes for the Enhancer