About Enhancer
| Enhancer ID: | E_02938 |
| Species: | Mus musculus |
| Position : | chr9:119377827-119389749   |
| Year: | 2019 |
| Title: | An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 31666509 |
| MONDO: | |
| Tissue: | Heart |
| Tissue Ontology ID: | UBERON:0000948 |
| Cell Source: | Cardiomyocytes |
| CVCL ID: | |
| Cell Type: | cardiomyocyte |
| Cell Ontology ID: | CL:0000746 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay, Chromatin interaction assay, TF binding assay |
| High Throughput Method: | ChIP-seq, RNA-seq, ATAC-seq, 4C-seq |
| Low Throughput Method: | Transgenic Reporter Assay, CRISPR Knockout, RT-RT-qPCR, Western blot, in vivo electrophysiology |
About Target Gene
| Target gene : | Scn5A |
About TF
| TF name : | Tbx3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Tbx3 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02937 | chr9:119377827-119379749 | Heart | cardiomyocyte | -- |
| E_03012 | chr9:119377827-119389749 | Heart | cardiomyocyte | -- |
| E_03266 | chr9:119378051-119379479 | Heart | cardiomyocyte | -- |
| E_02958 | chr9:119378700-119379271 | Heart | cardiomyocyte | -- |
| E_03109 | chr9:119380000-119389749 | Left Ventricle | cardiomyocyte | -- |
| E_03152 | chr9:119385000-119387000 | Heart | cardiomyocyte | -- |
Expression of Target Genes for the Enhancer