About Enhancer
| Enhancer ID: | E_02942 |
| Species: | Homo sapiens |
| Position : | chr2:234762042-234764060   |
| Year: | 2025 |
| Title: | Oncogenic HJURP enhancer promotes the aggressive behavior of triple-negative breast cancer in association with p53/E2F1/FOXM1-axis. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | triple-negative breast carcinoma |
| PMID: | 39736453 |
| MONDO: | MONDO:0005494 |
| Tissue: | breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | MDA-MB-231 |
| CVCL ID: | CVCL_0062 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF binding assay; functional perturbation assay |
| High Throughput Method: | H3K27ac ChIP-seq; RNA-seq; DNase-seq |
| Low Throughput Method: | dCas9-KRAB CRISPRi; ChIP-qPCR; dual-luciferase reporter assay; RT-qPCR; Western blot; CRISPRi |
About Target Gene
| Target gene : | HJURP |
About TF
| TF name : | FOXM1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOXM1 | Cyclin A/B1 associated events during G2/M transition | reactome | 22 |
| FOXM1 | FOXM1 transcription factor network | pid | 43 |
| FOXM1 | Polo-like kinase mediated events | reactome | 16 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
3 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02939 | chr2:234762042-234764060 | breast | malignant cell | triple-negative breast carcinoma |
| E_02940 | chr2:234762042-234764060 | breast | malignant cell | triple-negative breast carcinoma |
| E_02941 | chr2:234762042-234764060 | breast | malignant cell | triple-negative breast carcinoma |
Expression of Target Genes for the Enhancer