About Enhancer
| Enhancer ID: | E_02943 |
| Species: | Homo sapiens |
| Position : | chr3:15768491-15768703   |
| Year: | 2025 |
| Title: | Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2-Mediated Transcriptional Network in Multiple Myeloma. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | plasma cell myeloma |
| PMID: | 40167268 |
| MONDO: | MONDO:0009693 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Multiple myeloma cells |
| Cell Type: | plasma cell |
| Cell Ontology ID: | CL:0000786 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ATAC-seq; ChIP-seq; CUT&Tag; single-cell RNA-seq; RNA-seq |
| Low Throughput Method: | CRISPR knockout; CRISPRi; ChIP-RT-qPCR; FISH; CRISPR-Cas9 |
About Target Gene
| Target gene : | BCL2 |
About TF
| TF name : | POU2F2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| POU2F2 | BCR signaling pathway | pid | 70 |
| POU2F2 | RNA polymerase II transcribes snRNA genes | reactome | 70 |
| POU2F2 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02944 | chr3:15768491-15768703 | blood | plasma cell | plasma cell myeloma |
| E_02945 | chr3:15768491-15768703 | blood | plasma cell | plasma cell myeloma |
| E_02946 | chr3:15768491-15768703 | blood | plasma cell | plasma cell myeloma |
| E_02986 | chr3:15768491-15768703 | bone marrow | hematopoietic stem and progenitor cell | NA |
Expression of Target Genes for the Enhancer