About Enhancer
| Enhancer ID: | E_02956 |
| Species: | Homo sapiens |
| Position : | chr19:15311000-15312500   |
| Year: | 2020 |
| Title: | Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | lung adenocarcinoma |
| PMID: | 33219226 |
| MONDO: | MONDO:0005061 |
| Tissue: | lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | A-549 |
| CVCL ID: | CVCL_0023 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Functional perturbation assay, TF binding assay |
| High Throughput Method: | ChIP-seq; RNA-seq; ATAC-seq |
| Low Throughput Method: | CRISPR Knockout; ChIP-RT-qPCR; RT-RT-qPCR; Western blot |
About Target Gene
| Target gene : | NOTCH3 |
About TF
| TF name : | FOSL2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOSL2 | AP-1 transcription factor network | pid | 71 |
| FOSL2 | Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling (JNK cascade) ) | inoh | 5 |
| FOSL2 | Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling ) | inoh | 5 |
| FOSL2 | JNK cascade ( CD4 T cell receptor signaling (JNK cascade) ) | inoh | 12 |
| FOSL2 | JNK cascade ( CD4 T cell receptor signaling ) | inoh | 10 |
| FOSL2 | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | pid | 37 |
| FOSL2 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02954 | chr19:15311000-15312500 | lung | malignant cell | lung adenocarcinoma |
| E_02955 | chr19:15311000-15312500 | lung | malignant cell | lung adenocarcinoma |
| E_02957 | chr19:15311000-15312500 | lung | malignant cell | lung adenocarcinoma |
| E_02958 | chr19:15311000-15312500 | lung | malignant cell | lung adenocarcinoma |
| E_02959 | chr19:15311000-15312500 | lung | malignant cell | lung adenocarcinoma |
| E_03012 | chr19:15311000-15312500 | lung | malignant cell | lung adenocarcinoma |
Expression of Target Genes for the Enhancer