About Enhancer
| Enhancer ID: | E_02960 |
| Species: | Mus musculus |
| Position : | chr11:32144500-32150000   |
| Year: | 2025 |
| Title: | The ?|??-globin super-enhancer acts in an orientation-dependent manner |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 39863595 |
| MONDO: | |
| Tissue: | Fetal Liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | Erythroid cells |
| CVCL ID: | |
| Cell Type: | erythroid cell |
| Cell Ontology ID: | CL:0000038 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ATAC-seq, ChIP-seq, 3C-seq |
| Low Throughput Method: | CRISPR Knockout, RT-RT-qPCR |
About Target Gene
| Target gene : | Hba-A1 |
About TF
| TF name : | Gata1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata1 | C-MYB transcription factor network | pid | 87 |
| Gata1 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata1 | IL3 | netpath | 84 |
| Gata1 | Notch-mediated HES/HEY network | pid | 48 |
| Gata1 | p73 transcription factor network | pid | 80 |
| Gata1 | Signaling events mediated by HDAC Class I | pid | 89 |
| Gata1 | Signaling events mediated by HDAC Class II | pid | 58 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
7 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02653 | chr11:32115000-32145000 | Bone marrow | erythroid progenitor cell | -- |
| E_02961 | chr11:32145000-32145500 | Fetal Liver | erythroid cell | -- |
| E_03153 | chr11:32145270-32146411 | Blood vessel | endothelial cell | -- |
| E_02962 | chr11:32146000-32146500 | Fetal Liver | erythroid cell | -- |
| E_02963 | chr11:32147000-32147500 | Fetal Liver | erythroid cell | -- |
| E_02964 | chr11:32148000-32148500 | Fetal Liver | erythroid cell | -- |
| E_02965 | chr11:32149000-32149500 | Fetal Liver | erythroid cell | -- |
Expression of Target Genes for the Enhancer