About Enhancer
| Enhancer ID: | E_02970 |
| Species: | Mus musculus |
| Position : | chr15:63442671-63443111   |
| Year: | 2018 |
| Title: | A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 29342133 |
| MONDO: | MONDO:0018874 |
| Tissue: | Bone Marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | LSK Cells |
| CVCL ID: | |
| Cell Type: | hematopoietic stem cell |
| Cell Ontology ID: | CL:0001029 |
| Experiment Type: | Functional perturbation assay |
| High Throughput Method: | ChIP-seq, ATAC-seq |
| Low Throughput Method: | CRISPR Knockout, RT-RT-qPCR |
About Target Gene
| Target gene : | Myc |
About TF
| TF name : | Spi1 |
About Regulatory State
| Regulatory State : | Silenced |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Spi1 | C-MYB transcription factor network | pid | 87 |
| Spi1 | ERK cascade ( FGF8 signaling (Mouse) ) | inoh | 17 |
| Spi1 | ERK cascade ( FGF8 signaling (Xenopus) ) | inoh | 17 |
| Spi1 | FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) | inoh | 20 |
| Spi1 | FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) | inoh | 18 |
| Spi1 | Glucocorticoid receptor regulatory network | pid | 85 |
| Spi1 | IL4-mediated signaling events | pid | 66 |
| Spi1 | IL4 | netpath | 75 |
| Spi1 | Interleukin signaling pathway | panther | 86 |
| Spi1 | RANKL | netpath | 84 |
| Spi1 | Regulation of retinoblastoma protein | pid | 67 |
| Spi1 | Validated targets of C-MYC transcriptional repression | pid | 63 |
| Spi1 | Pathways in cancer | kegg | 321 |
| Spi1 | Acute myeloid leukemia | kegg | 53 |
| Spi1 | Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016 | wikipathways | 26 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer