About Enhancer
| Enhancer ID: | E_02977 |
| Species: | Mus musculus |
| Position : | chr17:45890060-45890829   |
| Year: | 2014 |
| Title: | The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 25030696 |
| MONDO: | |
| Tissue: | Bone Marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Bone marrow-derived macrophages |
| CVCL ID: | |
| Cell Type: | macrophage |
| Cell Ontology ID: | CL:0000235 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq, GRO-seq, 3C-seq |
| Low Throughput Method: | ChIP-RT-qPCR, RT-RT-qPCR, Luciferase Reporter Assay, 3C-RT-RT-qPCR, ELISA, CAM Assay |
About Target Gene
| Target gene : | Vegfa |
About TF
| TF name : | Rxra |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Rxra | a6b1 and a6b4 Integrin signaling | pid | 46 |
| Rxra | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| Rxra | Activation of gene expression by SREBF (SREBP) | reactome | 42 |
| Rxra | BMAL1:CLOCK,NPAS2 activates circadian gene expression | reactome | 42 |
| Rxra | Circadian Clock | reactome | 49 |
| Rxra | Endogenous sterols | reactome | 22 |
| Rxra | IL3 | netpath | 84 |
| Rxra | Import of palmitoyl-CoA into the mitochondrial matrix | reactome | 11 |
| Rxra | Nuclear Receptor transcription pathway | reactome | 51 |
| Rxra | PPARA activates gene expression | reactome | 113 |
| Rxra | Recycling of bile acids and salts | reactome | 15 |
| Rxra | Regulation of Androgen receptor activity | pid | 54 |
| Rxra | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | reactome | 20 |
| Rxra | Regulation of pyruvate dehydrogenase (PDH) complex | reactome | 14 |
| Rxra | Retinoic acid receptors-mediated signaling | pid | 30 |
| Rxra | RORA activates gene expression | reactome | 27 |
| Rxra | RXR and RAR heterodimerization with other nuclear receptor | pid | 26 |
| Rxra | Signaling by Retinoic Acid | reactome | 20 |
| Rxra | Synthesis of bile acids and bile salts | reactome | 7 |
| Rxra | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | reactome | 15 |
| Rxra | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | reactome | 24 |
| Rxra | TNFalpha | netpath | 274 |
| Rxra | Transcriptional activation of mitochondrial biogenesis | reactome | 43 |
| Rxra | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| Rxra | Vitamin D metabolism and pathway | panther | 6 |
| Rxra | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| Rxra | PPAR signaling pathway | kegg | 67 |
| Rxra | Adipocytokine signaling pathway | kegg | 65 |
| Rxra | Hepatitis C | kegg | 134 |
| Rxra | Pathways in cancer | kegg | 321 |
| Rxra | Thyroid cancer | kegg | 25 |
| Rxra | Small cell lung cancer | kegg | 83 |
| Rxra | Non-small cell lung cancer | kegg | 54 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer