About Enhancer
| Enhancer ID: | E_02985 |
| Species: | Homo sapiens |
| Position : | chr8:128206162-128314310   |
| Year: | 2018 |
| Title: | Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism. |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Normal |
| PMID: | 29641996 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | HCT 116 |
| CVCL ID: | CVCL_0291 |
| Experiment Type: | TF-binding/chromatin assay; Chromatin interaction assay; Endogenous enhancer perturbation |
| High Throughput Method: | ChIP-seq; ChIA-PET |
| Low Throughput Method: | CRISPR-Cas9 targeted editing/deletion; ChIP-qPCR/ChIP; 4C; RT-qPCR/qPCR |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
16 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03270 | chr8:128000000-128300000 | colon | malignant cell | colorectal cancer |
| E_01136 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01137 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01138 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01139 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01140 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01141 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_02910 | chr8:128220000-128250000 | heart | cardiac muscle cell | NA |
| E_02916 | chr8:128220000-128250000 | blood | lymphoblastoid cell | NA |
| E_03391 | chr8:128230172-128243000 | colon | NA | colorectal cancer |
| E_01855 | chr8:128230503-128232194 | colon | epithelial cell | colorectal carcinoma |
| E_04578 | chr8:128296257-128297326 | NA | NA | NA |
| E_04577 | chr8:128299198-128301336 | NA | NA | NA |
| E_03648 | chr8:128310315-128312315 | NA | NA | Medulloblastoma |
| E_03649 | chr8:128310315-128312315 | NA | NA | Medulloblastoma |
| E_03650 | chr8:128310315-128312315 | NA | NA | Medulloblastoma |
Expression of Target Genes for the Enhancer