About Enhancer
| Enhancer ID: | E_02986 |
| Species: | Homo sapiens |
| Position : | chr3:15768491-15768703   |
| Year: | 2025 |
| Title: | Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2-Mediated Transcriptional Network in Multiple Myeloma. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 40167268 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | CD34+ HSPCs |
| Cell Type: | hematopoietic stem and progenitor cell |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ATAC-seq; ChIP-seq; CUT&Tag; single-cell RNA-seq; RNA-seq |
| Low Throughput Method: | CRISPR knockout; CRISPRi; ChIP-RT-qPCR; FISH; CRISPR-Cas9 |
About Target Gene
| Target gene : | IRF4 |
About TF
| TF name : | POU2F2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| POU2F2 | BCR signaling pathway | pid | 70 |
| POU2F2 | RNA polymerase II transcribes snRNA genes | reactome | 70 |
| POU2F2 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02943 | chr3:15768491-15768703 | blood | plasma cell | plasma cell myeloma |
| E_02944 | chr3:15768491-15768703 | blood | plasma cell | plasma cell myeloma |
| E_02945 | chr3:15768491-15768703 | blood | plasma cell | plasma cell myeloma |
| E_02946 | chr3:15768491-15768703 | blood | plasma cell | plasma cell myeloma |
Expression of Target Genes for the Enhancer