About Enhancer
| Enhancer ID: | E_03000 |
| Species: | Homo sapiens |
| Position : | chr17:77922269-77927433   |
| Year: | 2021 |
| Title: | Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal cancer |
| PMID: | 34737287 |
| MONDO: | MONDO:0005575 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | 73 paired colorectal-cancer patient tissues |
| Cell Type: | epithelial cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Super-enhancer identification; endogenous epigenomic perturbation; oncogenic functional validation |
| High Throughput Method: | H3K27ac ChIP-seq; H3K4me3 ChIP-seq; RNA-seq; whole-genome sequencing; ROSE super-enhancer analysis; ChIP-seq |
| Low Throughput Method: | dCas9-KRAB CRISPRi; H3K27ac ChIP-qPCR; qRT-PCR; migration/Transwell assay; xenograft assay |
About Target Gene
| Target gene : | TBC1D16 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03024 | chr17:77922269-77927433 | colon | malignant cell | colorectal cancer |
Expression of Target Genes for the Enhancer