About Enhancer
| Enhancer ID: | E_03000 |
| Species: | Mus musculus |
| Position : | chr11:10941473-10942029   |
| Year: | 2018 |
| Title: | Sex reversal following deletion of a single far upstream enhancer of Sox9 |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | sex reversal |
| PMID: | 29903884 |
| MONDO: | MONDO:0008637 |
| Tissue: | Genital ridge |
| Tissue Ontology ID: | UBERON:0005294 |
| Cell Source: | Bipotential gonadal somatic cells |
| CVCL ID: | |
| Cell Type: | gonadal somatic cell |
| Cell Ontology ID: | CL:0000000 |
| Experiment Type: | Developmental biology assay, Functional genomics assay, Epigenomic profiling assay, Genome editing assay, Transcriptional regulation assay, In vivo transgenic reporter assay, In vivo functional assay |
| High Throughput Method: | ATAC-seq, ChIP-seq, DNase-seq |
| Low Throughput Method: | CRISPR-Cas9 enhancer deletion, RT-RT-qPCR, ChIP-RT-qPCR, LacZ Transgenic Reporter Assay, Immunofluorescence, H&E staining, FACS, Genotyping PCR, Sanger Sequencing |
About Target Gene
| Target gene : | Sox9 |
About TF
| TF name : | Sry; Sox9; Nr5A1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer