About Enhancer
| Enhancer ID: | E_03010 |
| Species: | Mus musculus |
| Position : | chr6:127006796-127007720   |
| Year: | 2018 |
| Title: | A Novel Distal Enhancer Mediates Inflammation-, PTH-, and Early Onset Murine Kidney Disease-Induced Expression of the Mouse Fgf23 Gene |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | chronic kidney disease |
| PMID: | 29527594 |
| MONDO: | MONDO:0005102 |
| Tissue: | Kidney |
| Tissue Ontology ID: | UBERON:0002113 |
| Cell Source: | Bone marrow-derived mesenchymal stem cells |
| CVCL ID: | |
| Cell Type: | mesenchymal stromal cell |
| Cell Ontology ID: | CL:0000134 |
| Experiment Type: | Functional genomics assay, Epigenomic profiling assay, Genome editing assay, Transcriptional regulation assay, In vivo functional assay |
| High Throughput Method: | ChIP-seq, Microarray, Comparative genomic conservation analysis |
| Low Throughput Method: | CRISPR-Cas9 enhancer deletion, RT-RT-qPCR, FGF23 ELISA, DXA, Serum biochemical analysis, Genotyping PCR, Sanger sequencing, In vivo LPS stimulation assay, In vivo cytokine stimulation assay, In vivo PTH stimulation assay, In vivo CKD model assay |
About Target Gene
| Target gene : | Fgf23 |
About TF
| TF name : | Nfkb1; Hif1A; Stat3; Stat5A; Stat6; Arnt; Clock; Arntl; Npas2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm10)
3 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03056 | chr6:127006900-127006914 | Kidney | osteocyte | chronic kidney disease |
| E_03057 | chr6:127007050-127007058 | Kidney | renal tubular epithelial cell | chronic kidney disease |
| E_03058 | chr6:127007200-127007209 | Kidney | renal proximal tubular epithelial cell | chronic kidney disease |
Expression of Target Genes for the Enhancer