About Enhancer
| Enhancer ID: | E_03012 |
| Species: | Homo sapiens |
| Position : | chr19:15311000-15312500   |
| Year: | 2020 |
| Title: | Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | lung adenocarcinoma |
| PMID: | 33219226 |
| MONDO: | MONDO:0005061 |
| Tissue: | lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | H2023 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Functional perturbation assay; TF binding assay |
| High Throughput Method: | NRF2 ChIP-seq; H3K27ac ChIP-seq; RNA-seq |
| Low Throughput Method: | NRF2 knockdown; ChIP-qPCR; RT-qPCR |
About Target Gene
| Target gene : | NOTCH3 |
About TF
| TF name : | NFE2L2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NFE2L2 | Protein processing in endoplasmic reticulum | kegg | 166 |
| NFE2L2 | Hs_Photodynamic_therapy-induced_unfolded_protein_response_WP3613_89330 | wikipathways | 6 |
| NFE2L2 | Hs_Transcriptional_activation_by_NRF2_WP3_79527 | wikipathways | 6 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02954 | chr19:15311000-15312500 | lung | malignant cell | lung adenocarcinoma |
| E_02955 | chr19:15311000-15312500 | lung | malignant cell | lung adenocarcinoma |
| E_02956 | chr19:15311000-15312500 | lung | malignant cell | lung adenocarcinoma |
| E_02957 | chr19:15311000-15312500 | lung | malignant cell | lung adenocarcinoma |
| E_02958 | chr19:15311000-15312500 | lung | malignant cell | lung adenocarcinoma |
| E_02959 | chr19:15311000-15312500 | lung | malignant cell | lung adenocarcinoma |
Expression of Target Genes for the Enhancer