About Enhancer
| Enhancer ID: | E_03049 |
| Species: | Mus musculus |
| Position : | chr13:74520100-74520400   |
| Year: | 2011 |
| Title: | AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 21081494 |
| MONDO: | |
| Tissue: | Liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | HEK293 cell line |
| CVCL ID: | CVCL_0045 |
| Cell Type: | embryonic kidney cell |
| Cell Ontology ID: | CL:0002139 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay |
About Target Gene
| Target gene : | Akr1B7 |
About TF
| TF name : | Nr1H4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Nr1H4 | Endogenous sterols | reactome | 22 |
| Nr1H4 | Nuclear Receptor transcription pathway | reactome | 51 |
| Nr1H4 | PPARA activates gene expression | reactome | 113 |
| Nr1H4 | Recycling of bile acids and salts | reactome | 15 |
| Nr1H4 | RXR and RAR heterodimerization with other nuclear receptor | pid | 26 |
| Nr1H4 | Synthesis of bile acids and bile salts | reactome | 7 |
| Nr1H4 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | reactome | 15 |
| Nr1H4 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | reactome | 24 |
| Nr1H4 | Hs_Drug_Induction_of_Bile_Acid_Pathway_WP2289_88593 | wikipathways | 9 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer