About Enhancer
| Enhancer ID: | E_03051 |
| Species: | Mus musculus |
| Position : | chr15:93680000-93682000   |
| Year: | 2010 |
| Title: | Widespread transcription at neuronal activity-regulated enhancers |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 20393465 |
| MONDO: | |
| Tissue: | Brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | Primary cortical neurons |
| CVCL ID: | |
| Cell Type: | cortical neuron |
| Cell Ontology ID: | CL:0000540 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, RT-RT-qPCR |
About Target Gene
| Target gene : | Arc |
About TF
| TF name : | Crebbp |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Crebbp | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| Crebbp | Activation of gene expression by SREBF (SREBP) | reactome | 42 |
| Crebbp | AndrogenReceptor | netpath | 167 |
| Crebbp | Attenuation phase | reactome | 28 |
| Crebbp | BMAL1:CLOCK,NPAS2 activates circadian gene expression | reactome | 42 |
| Crebbp | BMP signaling in Drosophila ( BMP signaling in Drosophila ) | inoh | 7 |
| Crebbp | BMP signaling in Drosophila (dorsal midline) ( BMP signaling in Drosophila ) | inoh | 7 |
| Crebbp | BMP signaling in Drosophila (dorsolateral) ( BMP signaling in Drosophila ) | inoh | 7 |
| Crebbp | BMP signaling pathway ( TGF-beta_BMP Diagram(MolecularVariation) ) | inoh | 34 |
| Crebbp | BMP2 signaling pathway(through Smad) ( TGF-beta_BMP Diagram(MolecularVariation) ) | inoh | 13 |
| Crebbp | C-MYB transcription factor network | pid | 87 |
| Crebbp | C. elegans Notch signaling pathway ( Notch signaling pathway Diagram ) | inoh | 8 |
| Crebbp | Canonical Notch signaling pathway ( Notch signaling pathway Diagram ) | inoh | 19 |
| Crebbp | CD209 (DC-SIGN) signaling | reactome | 21 |
| Crebbp | Circadian Clock | reactome | 49 |
| Crebbp | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | reactome | 57 |
| Crebbp | Constitutive Signaling by NOTCH1 PEST Domain Mutants | reactome | 57 |
| Crebbp | Direct p53 effectors | pid | 141 |
| Crebbp | E2F transcription factor network | pid | 77 |
| Crebbp | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Crebbp | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| Crebbp | FOXA1 transcription factor network | pid | 45 |
| Crebbp | FOXM1 transcription factor network | pid | 43 |
| Crebbp | FoxO family signaling | pid | 50 |
| Crebbp | Glucocorticoid receptor regulatory network | pid | 85 |
| Crebbp | HATs acetylate histones | reactome | 142 |
| Crebbp | Hedgehog | netpath | 39 |
| Crebbp | Hedgehog signaling events mediated by Gli proteins | pid | 49 |
| Crebbp | Hedgehog signaling pathway | panther | 19 |
| Crebbp | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | panther | 126 |
| Crebbp | HIF-1-alpha transcription factor network | pid | 67 |
| Crebbp | HIF-2-alpha transcription factor network | pid | 34 |
| Crebbp | Huntington disease | panther | 113 |
| Crebbp | Hypoxia response via HIF activation | panther | 16 |
| Crebbp | IFN-gamma pathway | pid | 43 |
| Crebbp | IL12 signaling mediated by STAT4 | pid | 33 |
| Crebbp | IL4 | netpath | 75 |
| Crebbp | IL6 | netpath | 85 |
| Crebbp | LIF signaling pathway ( LIF signaling(JAK1 JAK2 STAT3) ) | inoh | 10 |
| Crebbp | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | reactome | 5 |
| Crebbp | Mammalian Notch signaling pathway ( Notch signaling pathway Diagram ) | inoh | 15 |
| Crebbp | NICD traffics to nucleus | reactome | 13 |
| Crebbp | Notch-HLH transcription pathway | reactome | 13 |
| Crebbp | Notch-mediated HES/HEY network | pid | 48 |
| Crebbp | NOTCH1 Intracellular Domain Regulates Transcription | reactome | 47 |
| Crebbp | p53 pathway | panther | 39 |
| Crebbp | p53 pathway | pid | 59 |
| Crebbp | Posttranslational regulation of adherens junction stability and dissassembly | pid | 50 |
| Crebbp | PPARA activates gene expression | reactome | 113 |
| Crebbp | Pre-NOTCH Transcription and Translation | reactome | 29 |
| Crebbp | Presenilin action in Notch and Wnt signaling | pid | 46 |
| Crebbp | Prolactin | netpath | 105 |
| Crebbp | Regulation of Androgen receptor activity | pid | 54 |
| Crebbp | Regulation of gene expression by Hypoxia-inducible Factor | reactome | 10 |
| Crebbp | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | reactome | 20 |
| Crebbp | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Crebbp | Regulation of retinoblastoma protein | pid | 67 |
| Crebbp | Retinoic acid receptors-mediated signaling | pid | 30 |
| Crebbp | Role of Calcineurin-dependent NFAT signaling in lymphocytes | pid | 54 |
| Crebbp | RORA activates gene expression | reactome | 27 |
| Crebbp | Signaling events mediated by HDAC Class I | pid | 89 |
| Crebbp | Signaling events mediated by HDAC Class III | pid | 41 |
| Crebbp | Signaling events mediated by Stem cell factor receptor (c-Kit) | pid | 53 |
| Crebbp | Signaling events mediated by TCPTP | pid | 40 |
| Crebbp | Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 47 |
| Crebbp | Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 47 |
| Crebbp | Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 47 |
| Crebbp | Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| Crebbp | Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 47 |
| Crebbp | Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| Crebbp | Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 19 |
| Crebbp | TCR | netpath | 261 |
| Crebbp | TGF-beta signaling pathway | panther | 88 |
| Crebbp | TGF-beta_super_family_signaling_pathway(canonical) ( TGF-beta_BMP Diagram(MolecularVariation) ) | inoh | 51 |
| Crebbp | TGF_beta_Receptor | netpath | 220 |
| Crebbp | TNFalpha | netpath | 274 |
| Crebbp | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | reactome | 19 |
| Crebbp | TRAF3-dependent IRF activation pathway | reactome | 14 |
| Crebbp | TRAF6 mediated IRF7 activation | reactome | 33 |
| Crebbp | Transcription regulation by bZIP transcription factor | panther | 42 |
| Crebbp | Transcriptional activation of mitochondrial biogenesis | reactome | 43 |
| Crebbp | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| Crebbp | Validated targets of C-MYC transcriptional activation | pid | 80 |
| Crebbp | Wnt signaling pathway | panther | 250 |
| Crebbp | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| Crebbp | Cell cycle | kegg | 124 |
| Crebbp | Wnt signaling pathway | kegg | 135 |
| Crebbp | Notch signaling pathway | kegg | 44 |
| Crebbp | TGF-beta signaling pathway | kegg | 82 |
| Crebbp | Adherens junction | kegg | 70 |
| Crebbp | Jak-STAT signaling pathway | kegg | 149 |
| Crebbp | Long-term potentiation | kegg | 67 |
| Crebbp | Melanogenesis | kegg | 100 |
| Crebbp | Huntington's disease | kegg | 182 |
| Crebbp | Pathways in cancer | kegg | 321 |
| Crebbp | Renal cell carcinoma | kegg | 65 |
| Crebbp | Prostate cancer | kegg | 85 |
| Crebbp | Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 | wikipathways | 27 |
| Crebbp | Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 | wikipathways | 12 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer