About Enhancer
| Enhancer ID: | E_03053 |
| Species: | Homo sapiens |
| Position : | chr11:47394824-47395023   |
| Year: | 2014 |
| Title: | The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | RUNX1::RUNX1T1-associated acute myeloid leukemia |
| PMID: | 25185713 |
| MONDO: | MONDO:0018874 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | AML/ETO9a leukemia stem-cell models |
| Cell Type: | leukemia-initiating cell |
| Experiment Type: | Endogenous TF-site enhancer perturbation |
| High Throughput Method: | RNA-seq; hematopoietic profiling |
| Low Throughput Method: | Runx-site mutation; transplantation; leukemia latency analysis; RT-qPCR |
About Target Gene
| Target gene : | SPI1 |
About TF
| TF name : | RUNX1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| RUNX1 | AndrogenReceptor | netpath | 167 |
| RUNX1 | Organic cation transport | reactome | 9 |
| RUNX1 | RANKL | netpath | 84 |
| RUNX1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| RUNX1 | TGF_beta_Receptor | netpath | 220 |
| RUNX1 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| RUNX1 | Pathways in cancer | kegg | 321 |
| RUNX1 | Chronic myeloid leukemia | kegg | 69 |
| RUNX1 | Acute myeloid leukemia | kegg | 53 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer