About Enhancer
| Enhancer ID: | E_03058 |
| Species: | Mus musculus |
| Position : | chr6:127007200-127007209   |
| Year: | 2018 |
| Title: | A Novel Distal Enhancer Mediates Inflammation-, PTH-, and Early Onset Murine Kidney Disease-Induced Expression of the Mouse Fgf23 Gene |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | chronic kidney disease |
| PMID: | 29527594 |
| MONDO: | MONDO:0005102 |
| Tissue: | Kidney |
| Tissue Ontology ID: | UBERON:0002113 |
| Cell Source: | Renal proximal tubular epithelial cells |
| CVCL ID: | |
| Cell Type: | renal proximal tubular epithelial cell |
| Cell Ontology ID: | CL:0002306 |
| Experiment Type: | Functional genomics assay, Transcriptional regulation assay, In Silico Motif Analysis |
| High Throughput Method: | Whole-Genome TF Binding Motif Enrichment Analysis, ChIP-seq (Stat3, Stat5a) |
| Low Throughput Method: | EMSA, Dual-Luciferase Reporter Assay, qRT-PCR, ChIP-RT-qPCR |
About Target Gene
| Target gene : | Fgf23 |
About TF
| TF name : | Stat3; Stat5A |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03010 | chr6:127006796-127007720 | Kidney | mesenchymal stromal cell | chronic kidney disease |
Expression of Target Genes for the Enhancer