About Enhancer
| Enhancer ID: | E_03066 |
| Species: | Mus musculus |
| Position : | chr9:99032500-99032700   |
| Year: | 2015 |
| Title: | Pi3kcb Links Hippo-YAP and PI3K-AKT Signaling Pathways to Promote Cardiomyocyte Proliferation and Survival |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 25249570 |
| MONDO: | |
| Tissue: | Heart |
| Tissue Ontology ID: | UBERON:0000948 |
| Cell Source: | Neonatal rat ventricular cardiomyocytes |
| CVCL ID: | |
| Cell Type: | cardiomyocyte |
| Cell Ontology ID: | CL:0000746 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | Pik3Cb |
About TF
| TF name : | Yap1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Yap1 | ErbB4 signaling events | pid | 35 |
| Yap1 | Nuclear signaling by ERBB4 | reactome | 25 |
| Yap1 | p73 transcription factor network | pid | 80 |
| Yap1 | PPARA activates gene expression | reactome | 113 |
| Yap1 | Signaling by Hippo | reactome | 20 |
| Yap1 | TGF-beta receptor signaling | pid | 53 |
| Yap1 | TGF_beta_Receptor | netpath | 220 |
| Yap1 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| Yap1 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| Yap1 | Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 | wikipathways | 50 |
| Yap1 | Hs_miR-509-3p_alteration_of_YAP1-ECM_axis_WP3967_91491 | wikipathways | 14 |
| Yap1 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
| Yap1 | Hs_TGF-beta_Signaling_Pathway_WP366_90028 | wikipathways | 67 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03067 | chr9:99032500-99033051 | Heart | atrial cardiomyocyte | -- |
Expression of Target Genes for the Enhancer