About Enhancer
| Enhancer ID: | E_03068 |
| Species: | Mus musculus |
| Position : | chr1:172411511-172413110   |
| Year: | 2021 |
| Title: | ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 33044128 |
| MONDO: | |
| Tissue: | Heart |
| Tissue Ontology ID: | UBERON:0000948 |
| Cell Source: | Not available |
| CVCL ID: | |
| Cell Type: | cardiomyocyte |
| Cell Ontology ID: | CL:0000746 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ATAC-seq, RNA-seq, ChIP-seq |
| Low Throughput Method: | Transgenic Reporter Assay, X-gal Staining |
About Target Gene
| Target gene : | Rgs6 |
About TF
| TF name : | Mef2C |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Mef2C | CDO in myogenesis | reactome | 29 |
| Mef2C | Circadian Clock | reactome | 49 |
| Mef2C | ErbB1 downstream signaling | pid | 105 |
| Mef2C | ERK/MAPK targets | reactome | 17 |
| Mef2C | Notch | netpath | 76 |
| Mef2C | Oxidative stress response | panther | 23 |
| Mef2C | p38 MAPK pathway | panther | 31 |
| Mef2C | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Mef2C | Regulation of retinoblastoma protein | pid | 67 |
| Mef2C | Signaling events mediated by HDAC Class II | pid | 58 |
| Mef2C | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| Mef2C | TGF_beta_Receptor | netpath | 220 |
| Mef2C | Transcriptional activation of mitochondrial biogenesis | reactome | 43 |
| Mef2C | Trk receptor signaling mediated by the MAPK pathway | pid | 34 |
| Mef2C | MAPK signaling pathway | kegg | 264 |
| Mef2C | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| Mef2C | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| Mef2C | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| Mef2C | Hs_Oxidation_by_Cytochrome_P450_WP43_84102 | wikipathways | 14 |
| Mef2C | Hs_TGF-beta_Signaling_Pathway_WP366_90028 | wikipathways | 67 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02329 | chr1:172411511-172413110 | Heart | sinoatrial node pacemaker cell | -- |
Expression of Target Genes for the Enhancer