About Enhancer
| Enhancer ID: | E_03076 |
| Species: | Mus musculus |
| Position : | chr7:12705000-12706000   |
| Year: | 2014 |
| Title: | A negative feedback loop of transcription factors specifies alternative dendritic cell chromatin States |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 25453760 |
| MONDO: | |
| Tissue: | Bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Plasmacytoid dendritic cells (pDC) |
| CVCL ID: | |
| Cell Type: | plasmacytoid dendritic cell |
| Cell Ontology ID: | CL:0000786 |
| Experiment Type: | TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, ATAC-seq, RNA-seq |
| Low Throughput Method: | ChIP-RT-qPCR, shRNA knockdown, RT-RT-qPCR |
About Target Gene
| Target gene : | Siglech |
About TF
| TF name : | Irf8 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Irf8 | GMCSF-mediated signaling events | pid | 38 |
| Irf8 | Interferon alpha/beta signaling | reactome | 67 |
| Irf8 | Interferon gamma signaling | reactome | 88 |
| Irf8 | Validated targets of C-MYC transcriptional repression | pid | 63 |
| Irf8 | Hs_Type_II_interferon_signaling_(IFNG)_WP619_71168 | wikipathways | 10 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer