About Enhancer
| Enhancer ID: | E_03077 |
| Species: | Homo sapiens |
| Position : | chr15:66074477-66098025   |
| Year: | 2018 |
| Title: | Dissecting super-enhancer hierarchy based on chromatin interactions. |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Normal |
| PMID: | 29507293 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Erythroleukemia Cell,B lymphoblastoid Cell |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | TF-binding/chromatin assay; Chromatin interaction assay; Endogenous enhancer perturbation |
| High Throughput Method: | ChIP-seq; Hi-C |
| Low Throughput Method: | CRISPR-Cas9 targeted editing/deletion; ChIP-qPCR/ChIP |
About Target Gene
| Target gene : | SMYD3 |
About TF
| TF name : | GATA1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA1 | C-MYB transcription factor network | pid | 87 |
| GATA1 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA1 | IL3 | netpath | 84 |
| GATA1 | Notch-mediated HES/HEY network | pid | 48 |
| GATA1 | p73 transcription factor network | pid | 80 |
| GATA1 | Signaling events mediated by HDAC Class I | pid | 89 |
| GATA1 | Signaling events mediated by HDAC Class II | pid | 58 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
7 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03074 | chr15:66074477-66098025 | blood / hematopoietic system | malignant cell | NA |
| E_03075 | chr15:66074477-66098025 | blood / hematopoietic system | malignant cell | NA |
| E_03076 | chr15:66074477-66098025 | blood / hematopoietic system | malignant cell | NA |
| E_03078 | chr15:66074477-66098025 | blood / hematopoietic system | malignant cell | NA |
| E_03079 | chr15:66074477-66098025 | blood / hematopoietic system | malignant cell | NA |
| E_03080 | chr15:66074477-66098025 | blood / hematopoietic system | malignant cell | NA |
| E_03081 | chr15:66074477-66098025 | blood / hematopoietic system | malignant cell | NA |
Expression of Target Genes for the Enhancer