About Enhancer
| Enhancer ID: | E_03100 |
| Species: | Homo sapiens |
| Position : | chr21:39823183-39825183   |
| Year: | 2011 |
| Title: | ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 21536859 |
| MONDO: | MONDO:0004963 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | MOLT-4 |
| CVCL ID: | CVCL_0013 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF occupancy assay; Functional perturbation assay; In vivo enhancer reporter assay |
| Low Throughput Method: | Stable luciferase reporter assay; E-box/ETS/GATA motif mutagenesis; ChIP-PCR; ERG knockdown; RT-qPCR; Western blot; proliferation assay; transgenic mouse enhancer reporter assay |
About Target Gene
| Target gene : | ERG |
About TF
| TF name : | GATA3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA3 | C-MYB transcription factor network | pid | 87 |
| GATA3 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| GATA3 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA3 | Glucocorticoid receptor regulatory network | pid | 85 |
| GATA3 | IL27-mediated signaling events | pid | 26 |
| GATA3 | Notch signaling pathway | pid | 58 |
| GATA3 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| GATA3 | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| GATA3 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
17 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03098 | chr21:39823183-39825183 | blood | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03099 | chr21:39823183-39825183 | blood | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03101 | chr21:39823183-39825183 | blood | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03102 | chr21:39823183-39825183 | blood | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03103 | chr21:39823183-39825183 | blood | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03122 | chr21:39823183-39825183 | blood / hematopoietic system | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03123 | chr21:39823183-39825183 | blood / hematopoietic system | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03124 | chr21:39823183-39825183 | blood / hematopoietic system | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03125 | chr21:39823183-39825183 | blood / hematopoietic system | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03148 | chr21:39823183-39825183 | blood | NA | acute lymphoblastic leukemia |
| E_03149 | chr21:39823183-39825183 | blood | NA | acute lymphoblastic leukemia |
| E_03150 | chr21:39823183-39825183 | blood | NA | acute lymphoblastic leukemia |
| E_03151 | chr21:39823183-39825183 | blood | NA | acute lymphoblastic leukemia |
| E_03152 | chr21:39823183-39825183 | blood | NA | acute lymphoblastic leukemia |
| E_03153 | chr21:39823183-39825183 | blood | NA | acute lymphoblastic leukemia |
| E_03154 | chr21:39823183-39825183 | blood | NA | acute lymphoblastic leukemia |
| E_03155 | chr21:39823183-39825183 | blood | NA | acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer