About Enhancer
| Enhancer ID: | E_03110 |
| Species: | Homo sapiens |
| Position : | chr12:54624604-54625309   |
| Year: | 2025 |
| Title: | p300/CBP is an essential driver of pathogenic enhancer activity and gene expression in Ewing sarcoma. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Ewing sarcoma |
| PMID: | 40890402 |
| MONDO: | MONDO:0012817 |
| Tissue: | orbital region |
| Tissue Ontology ID: | UBERON:0004088 |
| Cell Source: | SK-N-MC |
| CVCL ID: | CVCL_0530 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer-associated functional perturbation assay; In vivo functional validation |
| High Throughput Method: | EWSR1::FLI1 ChIP-seq; histone-acetylation ChIP-seq; ribo-depleted RNA-seq |
| Low Throughput Method: | A-485 treatment; dCBP-1 treatment; CCS1477 treatment; enhancer RNA RT-qPCR; PPP1R1A RT-qPCR; In vivo phenotyping |
About Target Gene
| Target gene : | PPP1R1A |
About TF
| TF name : | EWSR1::FLI1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer