About Enhancer
| Enhancer ID: | E_03113 |
| Species: | Homo sapiens |
| Position : | chr11:17666830-17677080   |
| Year: | 2017 |
| Title: | PAX3-FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability. |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | alveolar rhabdomyosarcoma |
| PMID: | 28446439 |
| MONDO: | MONDO:0009994 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Human Fibroblast Cell Lines |
| Cell Type: | fibroblast |
| Cell Ontology ID: | CL:0000057 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Chromatin interaction assay; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; 4C; RT-qPCR/qPCR |
About Target Gene
| Target gene : | MYOD1 |
About TF
| TF name : | FOXO1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOXO1 | AKT phosphorylates targets in the nucleus | reactome | 9 |
| FOXO1 | AndrogenReceptor | netpath | 167 |
| FOXO1 | Angiopoietin receptor Tie2-mediated signaling | pid | 50 |
| FOXO1 | BCR | netpath | 161 |
| FOXO1 | Class I PI3K signaling events mediated by Akt | pid | 35 |
| FOXO1 | Constitutive Signaling by AKT1 E17K in Cancer | reactome | 25 |
| FOXO1 | CXCR4-mediated signaling events | pid | 87 |
| FOXO1 | EGFR1 | netpath | 475 |
| FOXO1 | FoxO family signaling | pid | 50 |
| FOXO1 | FSH | netpath | 44 |
| FOXO1 | IL-7 | netpath | 28 |
| FOXO1 | IL3 | netpath | 84 |
| FOXO1 | IL6-mediated signaling events | pid | 48 |
| FOXO1 | IL6 | netpath | 85 |
| FOXO1 | Insulin/IGF pathway-protein kinase B signaling cascade | panther | 22 |
| FOXO1 | Leptin | netpath | 98 |
| FOXO1 | MAPK6/MAPK4 signaling | reactome | 90 |
| FOXO1 | Negative regulation of gene expression ( Insulin receptor signaling (D. melanogaster) ) | inoh | 7 |
| FOXO1 | Negative regulation of gene expression ( Insulin receptor signaling (Mammal) ) | inoh | 7 |
| FOXO1 | PI3 kinase pathway | panther | 38 |
| FOXO1 | Regulation of Androgen receptor activity | pid | 54 |
| FOXO1 | Regulation of gene expression in beta cells | reactome | 17 |
| FOXO1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| FOXO1 | Signaling events mediated by HDAC Class III | pid | 41 |
| FOXO1 | TGF_beta_Receptor | netpath | 220 |
| FOXO1 | TNFalpha | netpath | 274 |
| FOXO1 | Insulin signaling pathway | kegg | 134 |
| FOXO1 | Pathways in cancer | kegg | 321 |
| FOXO1 | Prostate cancer | kegg | 85 |
| FOXO1 | Hs_ErbB_Signaling_Pathway_WP673_91869 | wikipathways | 37 |
| FOXO1 | Hs_Angiopoietin_Like_Protein_8_Regulatory_Pathway_WP3915_90629 | wikipathways | 9 |
| FOXO1 | Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 | wikipathways | 122 |
| FOXO1 | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| FOXO1 | Hs_Rac1-Pak1-p38-MMP-2_pathway_WP3303_87628 | wikipathways | 32 |
| FOXO1 | Hs_Energy_Metabolism_WP1541_91584 | wikipathways | 13 |
| FOXO1 | Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581 | wikipathways | 9 |
| FOXO1 | Hs_NAD_metabolism,_sirtuins_and_aging_WP3630_88178 | wikipathways | 8 |
| FOXO1 | Hs_AGE-RAGE_pathway_WP2324_89798 | wikipathways | 27 |
| FOXO1 | Hs_Follicle_Stimulating_Hormone_(FSH)_signaling_pathway_WP2035_86080 | wikipathways | 20 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03114 | chr11:17666830-17677080 | blood / hematopoietic system | fibroblast | alveolar rhabdomyosarcoma |
Expression of Target Genes for the Enhancer